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KMID : 0603520010060020067
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Journal of Korean Association of Cancer Prevention
2001 Volume.6 No. 2 p.67 ~ p.75
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Study on the Proper Composition of Human Papillomavirus Vaccine Based on the Prevalence of Ten High-risk Human Papillomaviruses Infection in Uterine Cervical Cancerous and Noncancerous Tissues Obtained from Korean Women
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Kim Moon-Hong
Kim Yong-Beom
Lee Chul-Min
Roh Ju-Won
Kim Jae-Won
Park Noh-Hyun
Song Yong-Sang
Kang Soon-Beom
Lee Hyo-Pyo
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Abstract
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Objective: Three are more than 20 cancer-associated HPV types, but little is known about the prevalence of HPV types in Korean women. Our aim was to investigate the prevalence of 10 high-risk HPV types in samples obtained from Korean women in order to establish a strategy of HPV vaccine development for Korean women.
Materials and Method: Cervical scrapes or tissues collected from a total of 781 women were tested for the presence of HPV types 16, 18, 31, 33, 35, 45, 51, 52, 56, 58 by multiplex nested PCR system developed by our laboratory recently.
Results: Among evaluable 751 samples, 153 with invasive cervical cancer (ICC), 56 with cervical intraepithelial neoplasia (CIN) and 542 with benign gynecologic disease(BGD), HPV DNA of any type was detected in 372 (49.5%) samples in total,71.9% in ICC, 67,9% in CIN, 41.3% in BGD. HPV 16 and 18 were detected in 77 and 19 cases of ICC, 26 and 5 cases of CIN, 125 and 30 of BGD, respectively. The most frequently detected HPV type in ICC was 16 and followed by 18, 33, 31, 52, 58, 51, 45, 56, 35 in decreasing order. Nearly 80% of ICC contain either HPV 16, 18, 31, or 33. Among 372 cases detected to contain HPV DNAs, 272 (73.1%) cases were infected with single HPV type, 79 (21.2%) cases with two types, 19 (5.1%) cases with three types, and only two cases with four types. There was significant difference in single infection rate between CIN and BGD, and borderline significance between cervical cancer and BGD.
Conclusions: In Korean women, mixed infection with multiple HPV types occurs in nearly 30% of infected women. HPV type distribution appears somewhat dissimilar in this report with that of previous reports from other countries. These data may be relevant to the rational design of prophylactic HPV vaccine strategies.
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KEYWORD
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Cervical cancer, Human papillomavirus, Multiplex PCR, Korean women, HPV vaccine
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